On 22 Apr 1433 John Duke Bedford (age 43) and Jacquetta Luxemburg (age 18) were married at Thérouanne [Map]. She by marriage Duchess Bedford. The difference in their ages was 25 years. She the daughter of Peter Luxemburg I Count Saint Pol (age 43) and Margherita Baux (age 39). He the son of King Henry IV of England and Mary Bohun. She a great x 5 granddaughter of King Henry III of England.

The marriage caused a rift with Philip "Good" Duke Burgundy (age 36), John's late wife's brother, who regarded the marriage, some five months after his sister's death, an insult to her memory. There was no issue from the marriage with John dying a year and a half later.