In 1652 [her father] Henry Cavendish 2nd Duke Newcastle upon Tyne (age 21) and [her mother] Frances Pierrepont Duchess Newcastle upon Tyne 1630-1695 (age 21) were married. He the son of William Cavendish 1st Duke Newcastle upon Tyne (age 59) and Elizabeth Bassett Countess Newcastle upon Tyne. They were second cousin once removed. He a great x 5 grandson of King Edward IV of England. 
On 22 Oct 1661 Margaret Cavendish Duchess Newcastle upon Tyne was born to Henry Cavendish 2nd Duke Newcastle upon Tyne (age 31) and Frances Pierrepont Duchess Newcastle upon Tyne 1630-1695 (age 31).
On 25 Dec 1676 [her grandfather] William Cavendish 1st Duke Newcastle upon Tyne (age 84) died at Welbeck Abbey [Map]. He was buried at Westminster Abbey [Map]. His son [her father] Henry Cavendish 2nd Duke Newcastle upon Tyne (age 46) succeeded 2nd Duke Newcastle upon Tyne, 2nd Earl Newcastle upon Tyne. [her mother] Frances Pierrepont Duchess Newcastle upon Tyne 1630-1695 (age 46) by marriage Duchess Newcastle upon Tyne.
On 21 May 1688 Thomas Pelham 1st Baron Pelham of Laughton (age 35) and [her future sister-in-law] Grace Holles Baroness Pelham were married. She the daughter of Gilbert Holles 3rd Earl de Clare 1633-1689 (age 55) and Grace Pierrepont Countess de Clare 1633-1702 (age 55).
On 16 Jan 1689 Gilbert Holles 3rd Earl de Clare 1633-1689 (age 55) died. His son [her future husband] John Holles 1st Duke Newcastle upon Tyne (age 27) succeeded 4th Earl Clare.
On 01 Mar 1690 John Holles 1st Duke Newcastle upon Tyne (age 28) and Margaret Cavendish Duchess Newcastle upon Tyne (age 28) were married. She by marriage Countess Clare. She the daughter of Henry Cavendish 2nd Duke Newcastle upon Tyne (age 59) and Frances Pierrepont Duchess Newcastle upon Tyne 1630-1695 (age 59). He the son of Gilbert Holles 3rd Earl de Clare 1633-1689 and Grace Pierrepont Countess de Clare 1633-1702 (age 57). They were first cousins.
On 26 Jul 1691 [her father] Henry Cavendish 2nd Duke Newcastle upon Tyne (age 61) died at Welbeck Abbey [Map]. Duke Newcastle upon Tyne, Earl Newcastle upon Tyne extinct.
In 1694 [her husband] John Holles 1st Duke Newcastle upon Tyne (age 31) was created 1st Duke Newcastle upon Tyne. Margaret Cavendish Duchess Newcastle upon Tyne (age 32) by marriage Duchess Newcastle upon Tyne.
On 11 Feb 1694 [her daughter] Henrietta Cavendish Holles Countess of Oxford and Mortimer 1694-1755 was born to [her husband] John Holles 1st Duke Newcastle upon Tyne (age 32) and Margaret Cavendish Duchess Newcastle upon Tyne (age 32). Coefficient of inbreeding 6.45%.
On 23 Sep 1695 [her mother] Frances Pierrepont Duchess Newcastle upon Tyne 1630-1695 (age 65) died.
On 13 Sep 1700 [her sister-in-law] Grace Holles Baroness Pelham died.
On 15 Jul 1711 [her husband] John Holles 1st Duke Newcastle upon Tyne (age 49) died. Duke Newcastle upon Tyne, Earl Clare extinct.
On 31 Aug 1713 [her son-in-law] Edward Harley 2nd Earl of Oxford and Earl Mortimer (age 24) and [her daughter] Henrietta Cavendish Holles Countess of Oxford and Mortimer 1694-1755 (age 19) were married. She the daughter of John Holles 1st Duke Newcastle upon Tyne and Margaret Cavendish Duchess Newcastle upon Tyne 1661-1716 (age 51). He the son of Robert Harley 1st Earl of Oxford and Earl Mortimer (age 51) and Elizabeth Foley Countess of Oxford and Mortimer.
On 24 Dec 1716 Margaret Cavendish Duchess Newcastle upon Tyne (age 55) died. She was buried in the St Mary and St Laurence's Church, Bolsover [Map].
1728. St Mary and St Laurence's Church, Bolsover [Map]. Monument to [her father] Henry Cavendish 2nd Duke Newcastle upon Tyne, [her mother] Frances Pierrepont Duchess Newcastle upon Tyne 1630-1695 and their daughter Margaret Cavendish Duchess Newcastle upon Tyne, and [her uncle] Charles Cavendish and Charles Cavendish sculpted by Francis Bird (age 61).
Charles Cavendish: Around 1626 he was born to William Cavendish 1st Duke Newcastle upon Tyne (age 33) and Elizabeth Bassett Countess Newcastle upon Tyne (age 34). In Jun 1659 Charles Cavendish (age 33) died.
Charles Cavendish: He was born to William Cavendish 3rd Earl Devonshire and Elizabeth Cecil Countess Devonshire 1619-1689. On 03 Mar 1671 he died.
Paternal Family Tree: Cavendish
Maternal Family Tree: Eleanor Gifford 1575
Kings Wessex: Great x 19 Grand Daughter of King Edmund "Ironside" I of England
Kings Gwynedd: Great x 14 Grand Daughter of Owain "Great" King Gwynedd 1100-1170
Kings Seisyllwg: Great x 20 Grand Daughter of Hywel "Dda aka Good" King Seisyllwg King Deheubarth
Kings Powys: Great x 15 Grand Daughter of Maredudd ap Bleddyn King Powys 1047-1132
Kings England: Great x 6 Grand Daughter of King Edward IV of England
Kings Scotland: Great x 14 Grand Daughter of William "Lion" I King Scotland
Kings Franks: Great x 15 Grand Daughter of Louis VII King Franks
Kings France: Great x 12 Grand Daughter of Philip "The Fair" IV King France
Great x 4 Grandfather: Thomas Cavendish
Great x 3 Grandfather: Thomas Cavendish 6 x Great Grand Son of King Edward "Longshanks" I of England
Great x 4 Grandmother: Catherine Scudamore 5 x Great Grand Daughter of King Edward "Longshanks" I of England
Great x 2 Grandfather: William Cavendish 7 x Great Grand Son of King Edward "Longshanks" I of England
Great x 4 Grandfather: John Carrington Smith
Great x 3 Grandmother: Alice Smith
Great x 1 Grandfather: Charles Cavendish 8 x Great Grand Son of King Edward "Longshanks" I of England
Great x 3 Grandfather: John Hardwick
Great x 2 Grandmother: Bess of Hardwick Countess Shrewsbury and Waterford
Great x 4 Grandfather: Thomas Leeke of Hasland
Great x 3 Grandmother: Elizabeth Leeke
Great x 4 Grandmother: Margaret Vaux
GrandFather: William Cavendish 1st Duke Newcastle upon Tyne 4 x Great Grand Son of King Edward IV of England
Great x 4 Grandfather: Robert Ogle 4th Baron Ogle 5 x Great Grand Son of King Edward III of England
Great x 3 Grandfather: Robert Ogle 5th Baron Ogle Great Grand Son of King Edward IV of England
Great x 4 Grandmother: Anne Lumley Baroness Ogle
Grand Daughter of King Edward IV of England
Great x 2 Grandfather: Cuthbert Ogle 7th Baron Ogle 2 x Great Grand Son of King Edward IV of England
Great x 1 Grandmother: Catherine Ogle 8th Baroness Ogle 3 x Great Grand Daughter of King Edward IV of England
Great x 3 Grandfather: Reginald Carnaby
Great x 2 Grandmother: Catherine Carnaby Baroness Ogle 7 x Great Grand Daughter of King Edward III of England
Great x 4 Grandfather: Thomas Forster III
Great x 3 Grandmother: Dorothy Forster 6 x Great Grand Daughter of King Edward III of England
Great x 4 Grandmother: Dorothy Ogle 5 x Great Grand Daughter of King Edward III of England
Father: Henry Cavendish 2nd Duke Newcastle upon Tyne 5 x Great Grand Son of King Edward IV of England
Great x 4 Grandfather: William Bassett 13 x Great Grand Son of King Henry I "Beauclerc" England
Great x 3 Grandfather: William Bassett 12 x Great Grand Son of King Henry "Curtmantle" II of England
Great x 4 Grandmother: Elizabeth Meverell 11 x Great Grand Daughter of King Henry "Curtmantle" II of England
Great x 2 Grandfather: William Bassett 13 x Great Grand Son of King Henry "Curtmantle" II of England
Great x 1 Grandfather: William Bassett 11 x Great Grand Son of King Henry "Curtmantle" II of England
Great x 4 Grandfather: Ralph Fitzherbert
8 x Great Grand Son of King Henry "Curtmantle" II of England
Great x 3 Grandfather: Anthony Fitzherbert 9 x Great Grand Son of King Henry "Curtmantle" II of England
Great x 4 Grandmother: Elizabeth Marshall
Great x 2 Grandmother: Elizabeth Fitzherbert 10 x Great Grand Daughter of King Henry "Curtmantle" II of England
Great x 4 Grandfather: Richard Cotton
Great x 3 Grandmother: Maud aka Matilda Cotton
Great x 4 Grandmother: Joan Brereton
GrandMother: Elizabeth Bassett Countess Newcastle upon Tyne 12 x Great Grand Daughter of King Henry "Curtmantle" II of England
Margaret Cavendish Duchess Newcastle upon Tyne 1661-1716 6 x Great Grand Daughter of King Edward IV of England
Great x 4 Grandfather: William Pierrepont 8 x Great Grand Son of King John "Lackland" of England
Great x 3 Grandfather: George Pierrepont 9 x Great Grand Son of King John "Lackland" of England
Great x 4 Grandmother: Joan Empson
Great x 2 Grandfather: Henry Pierrepont 10 x Great Grand Son of King John "Lackland" of England
Great x 4 Grandfather: William Thwaites
Great x 3 Grandmother: Winifred Thwaites
Great x 1 Grandfather: Robert Pierrepont 1st Earl Kingston 9 x Great Grand Son of King Edward "Longshanks" I of England
Great x 4 Grandfather: Thomas Cavendish 6 x Great Grand Son of King Edward "Longshanks" I of England
Great x 3 Grandfather: William Cavendish 7 x Great Grand Son of King Edward "Longshanks" I of England
Great x 4 Grandmother: Alice Smith
Great x 2 Grandmother: Frances Cavendish 8 x Great Grand Daughter of King Edward "Longshanks" I of England
Great x 4 Grandfather: John Hardwick
Great x 3 Grandmother: Bess of Hardwick Countess Shrewsbury and Waterford
Great x 4 Grandmother: Elizabeth Leeke
GrandFather: William Pierrepont of Thoresby 8 x Great Grand Son of King Edward III of England
Great x 4 Grandfather: Francis Talbot 5th Earl of Shrewsbury
4 x Great Grand Son of King Edward III of England
Great x 3 Grandfather: George Talbot 6th Earl of Shrewsbury 5 x Great Grand Son of King Edward III of England
Great x 4 Grandmother: Mary Dacre
5 x Great Grand Daughter of King Edward III of England
Great x 2 Grandfather: Henry Talbot 6 x Great Grand Son of King Edward III of England
Great x 4 Grandfather: Thomas Manners 1st Earl of Rutland
4 x Great Grand Son of King Edward III of England
Great x 3 Grandmother: Gertrude Manners Countess Shrewsbury and Waterford 1525-1567 5 x Great Grand Daughter of King Edward III of England
Great x 4 Grandmother: Eleanor Paston Countess Rutland
Great x 1 Grandmother: Gertrude Talbot Baroness Pierrepont Holme Pierrepoint 7 x Great Grand Daughter of King Edward III of England
Great x 2 Grandmother: Elizabeth Rayner
Mother: Frances Pierrepont Duchess Newcastle upon Tyne 1630-1695 9 x Great Grand Daughter of King Edward III of England
Great x 2 Grandfather: John Harries of Cruckton in Shropshire
Great x 1 Grandfather: Thomas Harries aka Harris 1st Baronet
Great x 3 Grandfather: Thomas Prowde of Sutton
Great x 2 Grandmother: Eleanor Prowde
GrandMother: Elizabeth Harries aka Harris
Great x 2 Grandfather: Roger Gifford Physican
Great x 1 Grandmother: Eleanor Gifford