The River Nene rises near Badby, Northamptonshire [Map] from where it flows past Newnham, Northamptonshire [Map], Weedon, Northamptonshire [Map], Nether Heyford, Northamptonshire [Map], Kinslingbury, Northamptonshire [Map], Hunsbury Meadows, Northamptonshire [Map], Northampton, Northamptonshire [Map], Billing, Northamptonshire [Map], Great Doddinton, Northamptonshire [Map], Rushden, Northamptonshire [Map], Thrapston, Northamptonshire [Map], around Oundle, Northamptonshire [Map], past St Mary and All Saints Church, Fotheringhay [Map] and the remains of Fotheringay Castle, Northamptonshire [Map], Wansford [Map], through the centre of Peterborough [Map] after which it is canalised to Rings End [Map]. After Rings End [Map] it continues through Wisbech, Cambridgeshire [Map], under Sutton Bridge [Map] after which it reaches The Wash at Guys Head [Map].

Durobrivae was a Roman fortified garrison town at Water Newton [Map] where Ermine Street crossed the River Nene in the territory of the Corieltauvi.