On 04 Aug 1598 [his grandfather] William Cecil 1st Baron Burghley (age 77) died. His son [his father] Thomas Cecil 1st Earl Exeter (age 56) succeeded 2nd Baron Burghley. He was buried at St Martin's Church, Stamford [Map] with a large free-standing Elizabethan Period monument under the north chapel arch, in coloured marbles with a figure on tomb chest under an arched canopy supported on paired columns. Attributed to Cornelius Cure. The emblem of the Knights of the Garter on William's left shoulder. Leg Garter. In his right-hand he is holding the Lord Treasurer Staff of Office; originally white.

The inscription one the monument is on contained within three panels: two on the south (Chancel) side, and one on the north (Chapel) side.

Sacred to God most good and great, and to memory. The most honourable and far renowned Lord William Cecil, Baron of Burghley, Lord High Treasurer of England, President of the Court of Wards, knight of the most noble order of the Garter, Privy Counsellor to the most serene Elizabeth, Queen of England, &c., and Chancellor of the University of Cambridge, under this tomb awaits the second coming of Christ: Who for the excellent endowments of the mind, was first made Privy Counsellor to Edward the sixth, King of England; afterwards to Queen Elizabeth: under whom being intrusted with the greatest and most weighty affairs of this kingdom, and above all others approved, in promoting the true religion, and providing for the safety and honour of the commonwealth; by his prudence, honesty, integrity, and great services to the nation, he obtained the highest honours: and when he had long enough to nature, long enough for glory, but not long enough to his country, quietly fell asleep in Christ. He had two wives: [his grandmother] Mary, sister of Sir John Cheeke, knight, of whom ie begat one son, Thomas (age 56), now Baron of Burghley; and Mildred, daughter of Sir Anthony Cooke, knight, who bore to him Sir [his uncle] Robert Cecil (age 35), knight, Privy Counsellor to Queen Elizabeth and President of the Court of Wards; [his aunt] Anne, married to Edward, Earl of Oxford (age 48); and [his aunt] Elizabeth (age 34) to William Wentworth, eldest son of Baron Wentworth.

Mary Cheke: she was born to Peter Cheke. In 1541 William Cecil 1st Baron Burghley and she were married. In Feb 1543 Mary Cheke died.

Elizabeth Cecil: On 01 Jul 1564 she was born to William Cecil 1st Baron Burghley and Mildred Cooke Baroness Burghley. On 26 Feb 1582 William Wentworth and she were married.